Rapid asymmetric cataract progression in patients following GLP-1 receptor agonist therapy: case series

Published Date: 07th October 2026

Publication Authors: Osman. M

Extract
Cataracts have various causes, the most common being slow progression of age-related change, which remains a leading cause of blindness worldwide. Possible Causes of rapidly developing cataracts include trauma, inflammation, radiation exposure, iatrogenic causes such as corticosteroid use, and metabolic abnormalities such as diabetes or electrolyte imbalance [1]. Glucagon-like peptide-1 (GLP-1) receptor agonists were originally developed for the treatment of type 2 diabetes mellitus, but, given their efficacy in weight management, they are now also widely used for obesity treatment [2]. Recent discussions have highlighted the possible eye-related complications linked to GLP-1 RAs, particularly their association with non-arteritic anterior ischemic optic neuropathy and the onset or worsening of diabetic retinopathy [3].

Eissa, M; Osman, M et al. (2026). Rapid asymmetric cataract progression in patients following GLP-1 receptor agonist therapy: case series. Eye. Pub online 07 Oct. [Online]. Available at: https://doi.org/10.1038/s41433-026-04971-7 [Accessed 14 October 2026].